A guide to anti-inflammatories for dogs

If you’ve heard of Advil or Aleve, you’re already somewhat familiar with NSAIDs. NSAIDs are used for pain relief. Just don’t use those brands for your dog!

🚨 Never give your dog over-the-counter pain relievers from the drug store, such as aspirin or Tylenol (acetaminophen), without first consulting your vet. These medicines are for human consumption and can cause emergency medical conditions in dogs.

Specifically formulated and branded NSAIDs are used to control pain and inflammation in dogs. They’re often prescribed for painful canine conditions such as osteoarthritis to manage pain and improve mobility. They may also be prescribed for post-operative pain management, or to treat musculoskeletal inflammation.

When cells in your dog’s body get damaged, they activate cyclooxygenase (COX), an enzyme that stimulates the production of prostaglandin compounds. Prostaglandins are found throughout a dog’s body and are important for sending chemical messages that protect the lining of the stomach, maintain blood flow to the kidneys, support blood clotting, and more. Prostaglandins are also responsible for inflammation and other symptoms, such as swelling and fever — acting as an alarm system when doggie cells are damaged.

NSAIDs for dogs inhibit the activation of the COX2 enzyme and inflammation-causing prostaglandins while allowing the body’s other prostaglandins to continue functioning normally. NSAIDs made for humans are less selective when it comes to inhibiting prostaglandin function because people are less sensitive to the negative effects of NSAIDs than dogs. That’s why you should never give your dog an NSAID intended for human use. 

A new medication called Galliprant works unlike traditional NSAIDs for dogs by leaving the production of prostaglandins totally unchanged, instead blocking a prostaglandin receptor associated with pain and inflammation. 

Benefits of NSAIDs in dogs

According to the FDA, the two key benefits Trusted Source U.S. Food and Drug Administration (FDA) Government agency. Go to source to NSAIDs that make them favored for doggie pain relief are:

1. They’re proven to be safe and effective when labels are properly followed
2. NSAID labels are specifically designed for dogs with all the information vets need for treatment

The Merck Veterinary Manual also notes that NSAIDs can produce positive results Trusted Source The Merck Veterinary Manual Trusted provider of veterinary medicine. Go to source without the side effects that can come with other medicines, such as corticosteroids. But that’s not to say NSAIDs don’t come without their own risks.

What are the side effects of NSAIDs for dogs?

Like any drug, NSAIDs can come with side effects. The Cornell University College of Veterinary Medicine outlines the most common: Trusted Source Cornell University College of Veterinary Medicine Veterinary school. Go to source

• Decrease or increase in appetite
• Change in bowel movements (diarrhea, bloody stool)
• Changes in behavior (activity level, aggression, incoordination, seizure)
• Changes in drinking habits (more or less water consumed)
• Change in urine (color, frequency, smell)
• Lethargy
• Skin conditions (redness, scabs, scratching, yellowing)

👉 If your dog experiences any of these symptoms after taking an NSAID, contact your vet immediately.

Remember how prostaglandins also protect the lining of the stomach, maintain blood flow to the kidneys, and support blood clotting? Non-selective NSAIDs that target all COX enzymes (such as human NSAIDs) over-inhibit prostaglandins, and can disrupt those positive bodily functions.

As a result, though extremely rare, NSAIDs can cause stomach ulcers, intestinal ulcers, intestinal bleeding, kidney failure, or liver failure. So, if your pup has any digestive, liver, or kidney conditions, be sure to inform your vet before treating them with NSAIDs.

Combining NSAIDs and other medication for dogs

Pet parents should take special care when treating their pets with NSAIDs. They shouldn’t be consumed while any other NSAIDs or steroids are present in the body. If at any point during the treatment you’re required to switch medications, most veterinarians recommend waiting a few days between taking your dog off the initial NSAID and getting them started on the new one. This gives their body time to flush out the old medication and minimizes the risk of adverse effects. 

👉 Make sure you notify your vet of any and all medications your dog is taking before receiving the NSAIDs, even if they are herbal or supplements.

Steroids are used for a wide range of doggie conditions from mild inflammation and allergic reactions (anti-itch) to arthritis and autoimmune (AI) disease. According to the Ryan Veterinary Hospital of the University of Pennsylvania, some steroids can even directly kill cancerous mast cells Trusted Source University of Pennsylvania School of Veterinary Medicine (Penn Vet) Veterinary school. Go to source while decreasing inflammation and the effects of degranulation, or the release of toxic substances into the bloodstream.

Also referred to as corticosteroids or cortisone, steroids are naturally-occuring hormones produced in dogs’ adrenal glands. Mineralocorticoids, like aldosterone, regulate the body’s electrolyte and water levels by retaining sodium in the kidneys, while glucocorticoids like cortisol are responsible for reducing inflammation caused by minor conditions or allergies. When provided in higher doses, steroids can act as an immunosuppressant.

According to VCA Animal Hospitals, synthetic steroids Trusted Source VCA Hospitals Community of veterinarians with up-to-date veterinary information. Go to source are the most commonly prescribed and are much more potent and long-lasting. These include prednisone, prednisolone, dexamethasone, triamcinolone, and methylprednisolone.

Benefits of steroids for dogs

Steroids have benefits that extend beyond treatment for inflammation. They’re a part of countless treatment regimens for many life-threatening diseases and illnesses, and when properly administered, have few side effects.

Steroids also come in varying forms. Some pups react more positively to specific applications over others (e.g., oral versus injection).

What are the side effects of steroids?

VCA Animal Hospital details the short-term side effects that can occur when dogs are initially placed on steroids. They include:

• Diabetes (in pre-diabetic dogs; often goes away upon the end of steroid use)
• Increased hunger, thirst, or urination
• Loss of energy
• Panting
• Vomiting or nausea
• Worsening of infections (e.g., skin infections)

After long-term use (3 to 4 months), other side effects can occur, including:

• Bacterial infections
• Calcinosis cutis (hard plaques on skin)
• Cushing’s disease
• Diminished wound healing ability
• Fungal infections
• Mange
• Muscle weakness
• Obesity
• Thin hair coat and skin
• Urinary tract infections (UTI)

At least one study Trusted Source PubMed Central Archive of biomedical and life sciences journal literature. Go to source also suggests that behavior changes — including restlessness, more frequent barking, aggression, avoidance, and general fearfulness — can occur in dogs treated with corticosteroids.

As with any medication, talk with your vet before administering steroids to your dog. Watch for any symptoms as they progress through the treatment and report them promptly. If any of the above symptoms occur, your vet may prescribe a different steroid to minimize side effects while continuing to treat your dog’s inflammation. 

Combining steroids and other doggie medications

Steroids shouldn’t be combined with any other drugs, including other anti-inflammatory drugs such as NSAIDs, or other forms of treatment unless specifically approved by your veterinarian.

Antihistamines are most commonly used in humans to treat seasonal allergies. But they can also be used to treat depression, anxiety, and motion sickness.

Though not FDA approved for dogs, the American Kennel Club reports that veterinarians may treat skin conditions, itching, motion sickness, Trusted Source The Merck Veterinary Manual Trusted provider of veterinary medicine. Go to source and anxiety in dogs with low-dosage, over-the-counter antihistamines, such as Benadryl. Trusted Source American Kennel Club (AKC) Registry of purebred dog pedigrees. Go to source

While some pet owners have found success with antihistamines and some studies Trusted Source PubMed Central Archive of biomedical and life sciences journal literature. Go to source confirm their success for treatment, other studies Trusted Source PubMed Central Archive of biomedical and life sciences journal literature. Go to source have found them to play no part in symptom improvement at best.

Antihistamines work by blocking histamine receptors in the body — in particular, the H1 histamine receptor found in mammals. Histamine is normally released when the body detects the presence of a harmful irritant or infection, causing the blood vessels to expand and the skin to swell. 

While this defense mechanism plays a key role in protecting the body from foreign invaders, people and dogs alike experience allergies when their body mistakes something harmless, like dust or pollen, for a threat and starts producing histamine in response. This results in an allergic reaction characterized by itchy, watery eyes, a runny or stuffy nose, sneezing, and skin rashes.  

Antihistamines have a variety of benefits for dogs. First, they’re generally safe in small doses and when strictly used under veterinary instruction. Second, they tend to be less of a “whomp” on the body than other anti-inflammatories — medicines like steroids tend to be more hard-hitting. Third, they can often be taken daily and for long-term treatment. Finally, they have a wide variety of applications, from relieving skin conditions to calming anxiety.

Common side effects of Benadryl and other antihistamines include:

• Drowsiness
• Dry mouth
• Hypersalivation
• Increased heart rate
• Rapid breathing
• Urinary retention

Rare, more serious side effects include:

• Decreased or increased appetite
• Diarrhea
• Vomiting

Dogs with cardiovascular disease, glaucoma, hypertension, hypothyroidism, lung disease, seizure disorders, or that are pregnant/nursing should always have vet approval before using an antihistamine.

As with other anti-inflammatory drugs, antihistamines shouldn’t be combined with any other drugs, including other anti-inflammatory drugs, unless specifically approved by your veterinarian. In some cases, concurrent use of antihistamines with corticosteroids like prednisone may prove beneficial in helping dogs ween off the steroid — but again, don’t do this unless your vet specifically instructs you to.

Oftentimes, inflammation and joint pain go hand-in-hand. Fortunately, joint supplements for dogs can help reduce the uncomfortable symptoms of osteoarthritis by supporting healthy ligaments and providing building blocks for cartilage regeneration to help get our four-legged friends back on their feet. Common ingredients include:

• Antioxidants. Prevent damage from free radicals.
• Glucosamine hydrochloride. An amino sugar that reduces inflammation and helps restore cartilage.
• Chondroitin sulfate. A compound that fights specific enzymes that harm cartilage.
• Collagen. A key compound found in connective tissues which deteriorates over time.
• Fish oil. A great source of omega-3 fatty acids.
• Green-lipped mussels. These ocean dwellers contain glucosamine, chondroitin, and fatty acids that aid in joint repair and reduce cartilage breakdown.

What’s more, joint supplements come in a variety of forms — chews, tablets, powders, liquids, and kibble — so you’re sure to find a fitting choice for Fido.

One joint supplement we love are these leading pain relief chews. Approved by the National Animal Supplement Council, Native Pet’s joint supplements always use clean, natural ingredients. These chews include green-lipped mussels, collagen, and more to support joint pain relief and combat inflammation. They have fantastic Amazon reviews and are suitable for dogs of all sizes!

Seasonal itchy skin and watery eyes are foe to both humans and our canine counterparts. Instead of meticulously cutting up micro-portions of Benadryl or risking human antihistamine complications, consider allergy immune supplements specifically designed for dogs, which use immune system-boosting ingredients to stave off allergy symptoms. Common ingredients found in allergy supplements include:

• Omega-3 and omega-6 fatty acids. Fish oil is often featured in supplements as it contains omega-3 and omega-6 fatty acids that naturally help relieve allergies, joint pain, and itchy skin.
• Probiotics. Many probiotics are live cultures like Lactobacillus.
• Turmeric. As noted with joint supplements, turmeric provides pain relief and has anti-inflammatory properties.
• Vitamin C. Vitamin C plays an important role in your dog’s health as it helps reduce inflammation, fights infections, and improves joint health.
• Vitamin E. Dogs need vitamin E to help skin cells function properly.

Like joint supplements, allergy immune supplements come in chew, tablet, liquid, and powder form for convenience.

Our favorite allergy immune supplement chews help relieve symptoms of seasonal, environmental, skin, and food allergies. They’re made in the USA and have outstanding reviews on Amazon, many of which call out how the supplements show improvement in just a matter of days.